Intake of wheat bran after administration of methylmercury reduces mercury accumulation in mice

Methylmercury (MeHg) exposure during pregnancy is a concern because of its potential health risks to the fetus. Wheat bran (bran), which outer layer wheat kernel, used as functional substance in food for specified uses Japan. In present study, we examined effect on accumulation and excretion Hg mice evaluate use reducing risk MeHg. Female BALB/cByJ were administered MeHg chloride (4 mg Hg/kg, p.o.). Immediately after administration, fed basal diet supplemented with 0%, 5%, or 15% bran, urine feces collected 14 days. The groups had lower total levels all tissues including brain compared control group, but effects significant only blood diet. Urinary was markedly higher than although there no difference between groups. Moreover, fecal substantially group dose-dependent. These results suggest that intake may enhance both decrease tissue levels. conclusion, dietary might be useful burden humans ingested food.